Quick Facts

Chemical Name
Growth Hormone Releasing Peptide-2
Also Known As
Pralmorelin, GHRP 2
Category
Growth Hormone
Administration
Subcutaneous injection on empty stomach

What is GHRP-2?

GHRP-2 (Pralmorelin) is a synthetic hexapeptide that acts as a growth hormone secretagogue. It was one of the first GHRPs developed and has been extensively studied for its ability to stimulate GH release. GHRP-2 occupies a middle ground between GHRP-6's strong appetite stimulation and Ipamorelin's selectivity, offering robust GH release with moderate effects on hunger and cortisol.

How Does GHRP-2 Work?

GHRP-2 binds to the growth hormone secretagogue receptor (GHSR-1a), the same receptor targeted by ghrelin. This binding triggers the release of growth hormone from the pituitary gland. Unlike Ipamorelin, GHRP-2 does cause some increase in cortisol and prolactin, though less than GHRP-6. It also has moderate effects on appetite stimulation through its ghrelin-mimetic activity.

Research-Backed Benefits

Strong GH Release

Strong Evidence

Produces robust growth hormone release, stronger than Ipamorelin but with more side effects.

Muscle Growth Support

Moderate Evidence

Elevated GH levels may support muscle protein synthesis and recovery.

Fat Metabolism

Moderate Evidence

GH elevation promotes lipolysis and may support body composition improvements.

Sleep Enhancement

Moderate Evidence

May improve sleep quality through GH modulation.

Anti-Aging Effects

Emerging Research

Addresses age-related GH decline with potential anti-aging benefits.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
100-300 mcg per dose
Frequency
2-3 times daily
Duration
8-16 weeks

Best taken on empty stomach. Often combined with GHRH peptides for synergistic effects.

Side Effects & Safety

  • Moderate hunger increase
  • Transient cortisol elevation
  • Possible prolactin increase
  • Water retention
  • Tingling or numbness

Frequently Asked Questions

GHRP-2 causes less hunger than GHRP-6 while still providing strong GH release. It's considered a middle ground between GHRP-6 and Ipamorelin.
Yes, combining GHRP-2 with a GHRH like CJC-1295 or Sermorelin produces synergistic GH release that exceeds either peptide alone.
GHRP-2 produces stronger GH release but has more side effects. Ipamorelin is 'cleaner' with fewer hormonal effects. Choice depends on priorities.

References

  1. Bowers CY, et al. "GHRP-2 effects on GH release." J Clin Endocrinol Metab, 1992. PMID: 1400879

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