Quick Facts

Chemical Name
Growth Hormone Releasing Peptide-6
Also Known As
Growth Hormone Releasing Hexapeptide, GHRP 6
Category
Growth Hormone
Administration
Subcutaneous injection on an empty stomach

What is GHRP-6?

GHRP-6 is a synthetic hexapeptide that belongs to the growth hormone secretagogue class. It was one of the earliest synthetic ghrelin mimetics developed and has been extensively studied. GHRP-6 is known for producing robust growth hormone release, but it also strongly stimulates appetite through its action on ghrelin receptors, making it distinct from other GHRPs like Ipamorelin.

How Does GHRP-6 Work?

GHRP-6 binds to the growth hormone secretagogue receptor (GHSR), which is the same receptor that ghrelin targets. This binding triggers GH release from the pituitary and also activates hunger signaling pathways. Unlike Ipamorelin, GHRP-6 also causes elevations in cortisol and prolactin, though these are typically transient and return to baseline.

Research-Backed Benefits

Potent GH Release

Strong Evidence

Produces robust growth hormone release, among the strongest of the GHRP family.

Appetite Stimulation

Strong Evidence

Significantly increases hunger, which can be beneficial for those seeking weight gain.

Muscle Growth Support

Moderate Evidence

Elevated GH may support muscle protein synthesis and recovery.

Improved Sleep

Moderate Evidence

May enhance sleep quality through GH modulation.

Gastric Protection

Emerging Research

Research suggests potential cytoprotective effects on the GI tract.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
100-300 mcg per dose
Frequency
2-3 times daily
Duration
8-16 weeks

Hunger spike occurs 20-30 minutes after injection. Often combined with GHRH peptides.

Side Effects & Safety

  • Intense hunger increase
  • Water retention
  • Cortisol elevation (transient)
  • Tingling or numbness

Frequently Asked Questions

GHRP-6 activates ghrelin receptors, which are responsible for hunger signaling. This makes it distinct from peptides like Ipamorelin that don't significantly affect appetite.
It depends on goals. GHRP-6 produces stronger GH release but also increases hunger and cortisol. Ipamorelin is 'cleaner' with fewer side effects.
Wait at least 20-30 minutes after injection before eating to maximize GH release. Many time their meals to coincide with the hunger spike.

References

  1. Bowers CY, et al. "Growth hormone-releasing peptide-6 stimulates GH release." Endocrinology, 1991. PMID: 1778629

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