Best Peptides for Fat Loss & Metabolism
Peptides researched for supporting fat metabolism, lipolysis, and healthy body composition.
Understanding Fat Loss & Metabolism
Fat loss and metabolism are areas of significant peptide research. Growth hormone plays an important role in fat metabolism, stimulating lipolysis (fat breakdown) and shifting the body toward using fat for fuel. Several peptides target these pathways, either by stimulating GH release or directly affecting fat cells. Research has been particularly active in developing peptides that can target fat metabolism without other hormonal effects.
How Peptides May Help
Peptides support fat loss through multiple mechanisms. GH secretagogues elevate growth hormone, which promotes lipolysis and fat oxidation. Some peptides like AOD-9604 are designed specifically to target the fat-metabolizing portions of GH without affecting blood sugar or growth. MOTS-c, a mitochondrial peptide, may improve metabolic function and insulin sensitivity. Tesamorelin is FDA-approved specifically for reducing visceral fat in certain populations.
Top Peptides for Fat Loss & Metabolism
Tesamorelin is the only GHRH peptide FDA-approved for reducing visceral fat. Clinical trials demonstrated significant reductions in trunk fat accumulation.
AOD-9604 is a fragment of HGH specifically designed to target fat metabolism without affecting blood sugar or growth. It has FDA GRAS status.
Ipamorelin stimulates GH release which promotes fat metabolism. Its clean profile with minimal cortisol elevation makes it suitable for fat loss phases.
MOTS-c is a mitochondrial peptide that activates AMPK and improves metabolic function. It's been called an 'exercise mimetic' for its metabolic effects.
CJC-1295 provides sustained GH elevation which supports fat metabolism, particularly when combined with Ipamorelin.
Research Summary
Clinical research on Tesamorelin demonstrated 15-18% reduction in visceral adipose tissue over 26 weeks in HIV patients with lipodystrophy. AOD-9604 studies showed increased lipolysis and inhibited lipogenesis in fat cells. Growth hormone research has consistently shown improvements in body composition, with increased lean mass and decreased fat mass. MOTS-c research in animals shows improved insulin sensitivity and resistance to obesity on high-fat diets. The combination of GH secretagogues with proper diet and exercise appears to enhance fat loss compared to lifestyle changes alone.
Frequently Asked Questions
References
- Falutz J, et al. "Tesamorelin reduces visceral fat." NEJM, 2007. PMID: 17989381
- Heffernan M, et al. "AOD9604 lipolytic effects." Obesity Research, 2003. PMID: 12972680
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