Peptide Comparison

GHRP-2 vs Ipamorelin

A detailed comparison to help you understand the differences and choose the right peptide for your research.

GH

GHRP-2

Growth Hormone
VS
Ip

Ipamorelin

Growth Hormone

GHRP-2 and Ipamorelin represent different philosophies in GH secretagogue development. GHRP-2 offers robust GH release with some hormonal effects, while Ipamorelin was developed for maximum selectivity. This comparison helps you understand the tradeoffs between potency and clean hormone profiles.

Quick Comparison

Aspect
GHRP-2
Ipamorelin
GH Release
Stronger GH release per dose
Slightly less potent but very consistent
Selectivity
Moderate - affects cortisol and prolactin
Highly selective - minimal other effects
Hunger Effect
Moderate increase
Minimal to none
Cortisol
Transient elevation
No significant effect
Prolactin
May increase slightly
No significant effect
Best For
Those prioritizing maximum GH
Those wanting clean, selective stimulation
Side Effect Profile
Moderate side effects
Minimal side effects
Cost
Generally less expensive
Slightly more expensive

Key Similarities

  • Both are growth hormone releasing peptides
  • Both work through ghrelin receptor
  • Both use similar dosing (100-300 mcg)
  • Both synergize with GHRH peptides
  • Both require empty stomach dosing
  • Both produce pulsatile GH patterns

Key Differences

  • GHRP-2 is more potent but less selective
  • Ipamorelin doesn't affect cortisol or prolactin
  • GHRP-2 causes more hunger increase
  • Ipamorelin has a 'cleaner' overall profile
  • GHRP-2 may be better for maximum GH goals
  • Ipamorelin preferred for long-term use

When to Choose Each

Choose GHRP-2

Choose GHRP-2 when maximum GH release is the priority and you can tolerate moderate side effects. Good for short-term intensive protocols or when cost is a factor.

Choose Ipamorelin

Choose Ipamorelin when you want selective GH stimulation without affecting other hormones. Ideal for long-term use, cutting phases, or when a clean profile is essential.

Can You Stack Them?

Both peptides can be combined with GHRH peptides for enhanced effects. Some researchers use both in rotation—GHRP-2 for intensive phases and Ipamorelin for maintenance.

Frequently Asked Questions

Ipamorelin's clean profile makes it preferable for extended protocols. Its lack of effect on cortisol and prolactin reduces potential issues with chronic use.
GHRP-2 may provide slightly more GH release, but Ipamorelin's selectivity often makes it the better choice when considering total effects.
Using both simultaneously would be redundant as they work through the same receptor. Choose one based on your priorities.

References

  1. Raun K, et al. "Ipamorelin selectivity." Eur J Endocrinol, 1998. PMID: 9758455

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