Peptide Comparison

GHRP-2 vs GHRP-6

A detailed comparison to help you understand the differences and choose the right peptide for your research.

GH

GHRP-2

Growth Hormone
VS
GH

GHRP-6

Growth Hormone

GHRP-2 and GHRP-6 are both potent growth hormone releasing peptides that work through the ghrelin receptor. While they share the same mechanism, they differ in potency, hunger effects, and hormonal side effects. Understanding these differences helps in selecting the right GHRP for specific research goals.

Quick Comparison

Aspect
GHRP-2
GHRP-6
GH Release Potency
Strong - slightly less than GHRP-6
Strongest among standard GHRPs
Hunger Increase
Moderate - noticeable but manageable
Intense - significant appetite spike
Cortisol Effect
Moderate transient increase
More significant cortisol elevation
Prolactin Effect
Slight increase possible
More notable prolactin elevation
Best Use Case
Balanced GH release with fewer side effects
Maximum GH and appetite stimulation
Cutting Phase
Better suited - less hunger
Less ideal due to hunger increase
Bulking Phase
Good option
Excellent - hunger helps caloric intake
Research History
Extensive clinical research
One of first GHRPs, extensive research

Key Similarities

  • Both are hexapeptide GH secretagogues
  • Both work through the ghrelin receptor (GHSR)
  • Both use similar dosing protocols (100-300 mcg)
  • Both synergize with GHRH peptides
  • Both should be taken on empty stomach
  • Both produce pulsatile GH release

Key Differences

  • GHRP-6 causes more intense hunger than GHRP-2
  • GHRP-6 produces slightly stronger GH release
  • GHRP-2 has less effect on cortisol levels
  • GHRP-2 is often preferred for cutting phases
  • GHRP-6 is popular for bulking due to appetite increase
  • GHRP-2 is considered 'cleaner' than GHRP-6

When to Choose Each

Choose GHRP-2

Choose GHRP-2 when you want strong GH release with moderate hunger and fewer hormonal side effects. It's the better choice during cutting phases or when appetite increase is undesirable.

Choose GHRP-6

Choose GHRP-6 when maximum GH release is the priority and increased appetite is either beneficial or acceptable. Ideal for bulking phases when extra calories are needed.

Can You Stack Them?

Both GHRP-2 and GHRP-6 work synergistically with GHRH peptides like CJC-1295 or Sermorelin. Combining them amplifies GH release beyond either alone. Some researchers alternate between the two based on training phases.

Frequently Asked Questions

GHRP-6 produces slightly stronger GH release than GHRP-2 at equivalent doses, though the difference is modest.
Yes, they can be used interchangeably. Some use GHRP-6 during bulking and switch to GHRP-2 for cutting.
Both improve sleep through GH enhancement. GHRP-2's moderate profile may be preferable if nighttime hunger is a concern.

References

  1. Bowers CY. "Comparison of GHRPs." J Clin Endocrinol Metab, 1998. PMID: 9768674

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