Quick Facts

Chemical Name
Growth Hormone Releasing Hexapeptide
Also Known As
Examorelin, HEX
Category
Growth Hormone
Administration
Subcutaneous injection on empty stomach

What is Hexarelin?

Hexarelin is a synthetic hexapeptide and the most potent growth hormone releasing peptide (GHRP) available. It produces significantly stronger GH release than other GHRPs like GHRP-6 or GHRP-2. Beyond its GH-releasing effects, Hexarelin has unique cardioprotective properties mediated through cardiac-specific receptors, making it of interest for both performance and cardiovascular research.

How Does Hexarelin Work?

Hexarelin activates the GHSR-1a receptor with high potency, triggering robust GH release from the pituitary. Its superior potency comes from optimized binding characteristics. Uniquely, Hexarelin also binds to CD36 receptors in cardiac tissue, providing cardioprotective effects independent of GH release. It increases cortisol and prolactin more than other GHRPs.

Research-Backed Benefits

Maximum GH Release

Strong Evidence

Produces the strongest GH release of any GHRP, exceeding GHRP-6 and GHRP-2.

Cardioprotective Effects

Moderate Evidence

Unique benefits for heart tissue through CD36 receptor activation, independent of GH.

Muscle Growth

Moderate Evidence

Strong GH elevation supports muscle protein synthesis and recovery.

Rapid Desensitization

Strong Evidence

Develops tolerance faster than other GHRPs, requiring careful cycling.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
100-200 mcg per dose
Frequency
2-3 times daily
Duration
4-8 weeks (shorter cycles due to desensitization)

Develops tolerance faster than other GHRPs. Requires cycling with breaks to maintain sensitivity.

Side Effects & Safety

  • Significant cortisol elevation
  • Prolactin increase
  • Water retention
  • Hunger increase
  • Rapid receptor desensitization

Frequently Asked Questions

Hexarelin has optimized binding characteristics for the GHSR-1a receptor, producing GH release that exceeds other GHRPs at equivalent doses.
Hexarelin causes rapid receptor desensitization, meaning the body's response decreases with continuous use. Cycling with breaks helps maintain sensitivity.
Hexarelin binds to CD36 receptors in cardiac tissue, providing cardioprotective effects independent of GH release. This makes it unique among GHRPs.

References

  1. Berlanga J, et al. "Hexarelin cardioprotective effects." Growth Horm IGF Res, 1999. PMID: 10501877

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