Quick Facts

Chemical Name
Body Protection Compound-157
Also Known As
BPC 157, Pentadecapeptide
Category
Healing & Regeneration
Administration
Commonly researched in oral or injectable forms

What is BPC-157?

BPC-157 is a synthetic pentadecapeptide consisting of 15 amino acids. It is derived from a protective protein found in the stomach, where it plays a role in maintaining gut integrity and promoting healing. Research has demonstrated remarkable regenerative properties across multiple tissue types, making it one of the most studied peptides in the regenerative medicine field. The compound works through multiple mechanisms including angiogenesis promotion, growth factor modulation, and nitric oxide system regulation.

How Does BPC-157 Work?

BPC-157 exerts its effects through several interconnected pathways. It upregulates growth hormone receptors, promotes angiogenesis (new blood vessel formation), and modulates the nitric oxide system. The peptide interacts with the dopaminergic and GABAergic systems, contributing to its systemic effects. Research suggests it may also influence the FAK-paxillin pathway, which is crucial for cell migration and tissue repair. Additionally, BPC-157 has been shown to counteract the effects of NSAIDs on the gastrointestinal tract and may protect against various toxic insults.

Research-Backed Benefits

Accelerated Tissue Repair

Strong Evidence

Promotes healing of tendons, ligaments, muscles, and bone tissue through enhanced collagen synthesis and angiogenesis.

Gastrointestinal Protection

Strong Evidence

Supports gut lining integrity, may help with inflammatory bowel conditions, and protects against NSAID-induced damage.

Anti-Inflammatory Effects

Moderate Evidence

Reduces inflammation markers and may help modulate the inflammatory response in various tissues.

Joint Health Support

Moderate Evidence

May promote healing of damaged cartilage and support overall joint function and mobility.

Neuroprotective Properties

Emerging Research

Research suggests potential benefits for nerve healing and protection against certain neurotoxic compounds.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
200-800 mcg per day
Frequency
1-2 times daily
Duration
4-12 weeks typical research protocols

Can be administered orally or via subcutaneous injection. Oral bioavailability is debated but supported by some research.

Side Effects & Safety

  • Generally well-tolerated in research settings
  • Rare reports of nausea at higher doses
  • Potential for injection site reactions
  • Limited long-term safety data in humans

Frequently Asked Questions

BPC-157 is primarily researched for its tissue healing properties, including tendon repair, gut healing, and anti-inflammatory effects. It's studied in contexts of injury recovery and gastrointestinal health.
Research protocols typically show effects within 1-2 weeks for acute injuries, with optimal results often observed after 4-6 weeks of consistent administration.
BPC-157 is legal to purchase for research purposes in most countries. However, it is not approved by the FDA for human use and is banned by WADA in competitive sports.
Yes, oral administration is one method studied in research. While some debate its oral bioavailability, studies have shown systemic effects from oral dosing.
Both are healing peptides, but they work through different mechanisms. BPC-157 primarily affects the gut-brain axis and local tissue healing, while TB-500 works more systemically through actin regulation.

References

  1. Sikiric P, et al. "Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model." European Journal of Pharmacology, 2018. PMID: 29655969
  2. Seiwerth S, et al. "Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease." Current Pharmaceutical Design, 2018. PMID: 29737246
  3. Sikiric P, et al. "BPC 157 and healing." Journal of Physiology Paris, 2019. PMID: 31234890

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