Quick Facts

Chemical Name
Thymosin Beta-4 Fragment
Also Known As
Thymosin Beta 4, TB4
Category
Healing & Regeneration
Administration
Administered via subcutaneous or intramuscular injection

What is TB-500?

TB-500 is a synthetic version of the active region of thymosin beta-4, a 43-amino acid protein found in virtually all human and animal cells. The natural protein is particularly concentrated in blood platelets and wound fluid, reflecting its critical role in the healing process. TB-500 contains the active segment responsible for actin-binding and cell migration properties, making it highly researched for its potential in accelerating recovery from injuries.

How Does TB-500 Work?

TB-500 works primarily through its interaction with actin, a protein that forms the cytoskeleton of cells. By binding to actin, TB-500 promotes cell migration, blood vessel formation, and wound healing. It upregulates actin production and facilitates its organization, which is essential for cell movement to injury sites. Additionally, TB-500 has anti-inflammatory properties and promotes the formation of new blood vessels, ensuring adequate blood supply to healing tissues.

Research-Backed Benefits

Tissue Regeneration

Strong Evidence

Promotes healing of muscles, tendons, ligaments, and skin through enhanced cell migration.

Reduced Inflammation

Moderate Evidence

Decreases inflammatory markers and may help modulate the inflammatory response.

Improved Flexibility

Moderate Evidence

May enhance tissue flexibility and reduce scarring during the healing process.

Cardiovascular Support

Emerging Research

Research suggests potential benefits for heart tissue repair and blood vessel health.

Hair Growth

Emerging Research

May stimulate hair follicle stem cells and promote hair regrowth.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
2-5 mg per week
Frequency
1-2 times weekly
Duration
4-8 weeks for acute injuries, longer for chronic conditions

Loading phase of 4-6 weeks often followed by maintenance dosing.

Side Effects & Safety

  • Generally well tolerated
  • Head rush shortly after injection
  • Temporary lethargy possible
  • Injection site irritation

Frequently Asked Questions

TB-500 is researched primarily for tissue healing, including muscle, tendon, and ligament repair. It's also studied for its anti-inflammatory and cardiovascular benefits.
Some users report initial improvements within 1-2 weeks, with more significant results after 4-6 weeks of consistent use.
TB-500 is a synthetic fragment containing the active region of thymosin beta-4. It's designed to replicate the healing properties of the full protein.
Yes, TB-500 and BPC-157 are commonly used together in research as they work through different mechanisms and may have synergistic effects.
TB-500 has systemic distribution, so it can be injected subcutaneously anywhere. The injection site does not need to be near the injury.

References

  1. Crockford D, et al. "Thymosin beta4: a multi-functional regenerative peptide." Annals of the New York Academy of Sciences, 2010. PMID: 20633111
  2. Smart N, et al. "Thymosin beta-4 and cardiac repair." Expert Opinion on Biological Therapy, 2008. PMID: 18473704

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