Quick Facts

Chemical Name
Human Growth Hormone Fragment 176-191
Also Known As
HGH Frag, Frag 176-191
Category
Metabolic & Fat Loss
Administration
Subcutaneous injection, typically in abdominal area

What is HGH Fragment 176-191?

HGH Fragment 176-191 represents the tail end of the growth hormone molecule, specifically the portion responsible for fat metabolism. This synthetic fragment provides the fat-burning effects of HGH without affecting blood glucose or promoting growth. It's essentially a more targeted version of AOD-9604, which has an additional tyrosine modification. The fragment stimulates lipolysis and inhibits lipogenesis without the broader hormonal effects of full growth hormone.

How Does HGH Fragment 176-191 Work?

Fragment 176-191 mimics how natural GH regulates fat metabolism but doesn't interact with the GH receptor. It stimulates lipolysis (fat breakdown) by acting on adipocytes through mechanisms that may involve beta-3 adrenergic receptors. Unlike full GH, it doesn't cause IGF-1 elevation, blood glucose changes, or tissue growth effects.

Research-Backed Benefits

Targeted Fat Loss

Moderate Evidence

Specifically promotes lipolysis without growth effects.

No Blood Sugar Impact

Strong Evidence

Doesn't affect glucose levels or insulin sensitivity.

No Growth Effects

Strong Evidence

Won't cause tissue growth or IGF-1 elevation.

Lipogenesis Inhibition

Moderate Evidence

May prevent new fat formation.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
250-500 mcg per day
Frequency
1-2 times daily
Duration
8-16 weeks

Best taken on empty stomach. Morning and pre-workout are popular timing.

Side Effects & Safety

  • Generally well tolerated
  • Injection site irritation
  • Possible headache
  • Minimal systemic effects

Frequently Asked Questions

They're very similar. AOD-9604 is Fragment 176-191 with a tyrosine attached for stability. Effects are essentially the same, though AOD-9604 has more clinical research.
Fragment 176-191 is more targeted for fat loss without GH's growth effects or blood sugar impact. However, full GH provides broader benefits beyond fat loss.
Yes, it's often combined with GH secretagogues or other fat loss peptides. Since it doesn't affect the GH receptor, there's no direct conflict.

References

  1. Ng FM, et al. "GH fragment lipolytic effects." J Endocrinol, 2000. PMID: 10801956

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