Quick Facts

Chemical Name
Anti-Obesity Drug 9604
Also Known As
AOD 9604, HGH Fragment 177-191
Category
Metabolic & Fat Loss
Administration
Subcutaneous injection, typically in the abdominal area in the morning

What is AOD-9604?

AOD-9604 is a synthetic peptide fragment of human growth hormone, specifically the portion corresponding to amino acids 176-191 with a tyrosine substitution. It was developed by Metabolic Pharmaceuticals in Australia to capture the fat-metabolizing effects of HGH without the growth-promoting or diabetogenic effects. The peptide has received GRAS (Generally Recognized as Safe) status from the FDA for use in food.

How Does AOD-9604 Work?

AOD-9604 mimics the fat-reducing effects of natural growth hormone but works through a different mechanism. It stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat formation) without activating the HGH receptor. This means it doesn't affect blood glucose levels or cause growth effects. It appears to work by regulating fat metabolism through beta-3 adrenergic receptors.

Research-Backed Benefits

Fat Metabolism

Moderate Evidence

Specifically targets fat cells to promote lipolysis without affecting growth.

No Blood Sugar Impact

Strong Evidence

Does not affect insulin sensitivity or blood glucose levels.

No Growth Effects

Strong Evidence

Does not cause the growth-promoting effects of full HGH.

GRAS Status

Strong Evidence

Has received FDA GRAS status for use in food products.

Cartilage Repair

Emerging Research

Research suggests potential benefits for cartilage regeneration.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
250-500 mcg per day
Frequency
Once daily, typically morning
Duration
12-24 weeks

Often administered on an empty stomach. May be combined with exercise for enhanced effects.

Side Effects & Safety

  • Generally well tolerated
  • Injection site reactions (rare)
  • Headache (uncommon)
  • Flu-like symptoms (rare)

Frequently Asked Questions

No, AOD-9604 is only a small fragment of HGH (amino acids 176-191) that specifically affects fat metabolism without the growth or blood sugar effects of full HGH.
Research has shown it can stimulate lipolysis and inhibit fat formation, though results vary. It works best when combined with diet and exercise.
AOD-9604 has FDA GRAS (Generally Recognized as Safe) status for use in food, but is not FDA approved as a drug.

References

  1. Heffernan M, et al. "AOD9604 peptide and fat metabolism." Obesity Research, 2003. PMID: 12972680

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