Peptide Comparison

AOD-9604 vs HGH Fragment 176-191

A detailed comparison to help you understand the differences and choose the right peptide for your research.

AO

AOD-9604

Metabolic & Fat Loss
VS
HG

HGH Fragment 176-191

Metabolic & Fat Loss

AOD-9604 and HGH Fragment 176-191 are closely related peptides that target fat metabolism. In fact, AOD-9604 is essentially Fragment 176-191 with an additional tyrosine modification. Understanding their subtle differences helps choose the right fat-loss peptide.

Quick Comparison

Aspect
AOD-9604
HGH Fragment 176-191
Structure
HGH Fragment 176-191 + Tyrosine
Pure HGH amino acids 176-191
Stability
Enhanced stability from tyrosine
Standard peptide stability
Research
More clinical trials; GRAS status
Less formal research
Regulatory Status
FDA GRAS for food use
Research peptide only
Mechanism
Lipolysis stimulation, lipogenesis inhibition
Same mechanism
Blood Sugar
No effect
No effect
Growth Effects
None
None
Typical Cost
Often slightly more expensive
Often slightly less expensive

Key Similarities

  • Both target fat metabolism specifically
  • Both stimulate lipolysis and inhibit lipogenesis
  • Both have no effect on blood glucose
  • Both cause no growth effects
  • Both use similar dosing protocols
  • Both work independently of GH receptor

Key Differences

  • AOD-9604 has additional tyrosine for stability
  • AOD-9604 has more formal clinical research
  • AOD-9604 has FDA GRAS status
  • Fragment 176-191 may be less expensive
  • AOD-9604 may have slightly better bioavailability
  • Fragment 176-191 is the 'pure' sequence

When to Choose Each

Choose AOD-9604

Choose AOD-9604 when you want the more researched version with FDA GRAS status. Its tyrosine modification may provide better stability and the additional clinical data offers more confidence.

Choose HGH Fragment 176-191

Choose HGH Fragment 176-191 when you prefer the pure, unmodified sequence or when cost is a significant factor. Effects are essentially equivalent to AOD-9604.

Can You Stack Them?

Using both together is unnecessary as they're nearly identical. Either can be combined with GH secretagogues for complementary effects—secretagogues for GH benefits, fragments for targeted fat loss.

Frequently Asked Questions

Nearly identical. AOD-9604 is Fragment 176-191 with an added tyrosine that improves stability. Functional effects are essentially the same.
They're equivalent in mechanism. AOD-9604's stability modification may provide slightly more consistent results, but real-world differences are minimal.
AOD-9604 underwent clinical development and safety testing for potential drug approval, earning GRAS status. Fragment 176-191 wasn't submitted for similar review.

References

  1. Heffernan M, et al. "AOD9604 lipolytic effects." Obesity Research, 2003. PMID: 12972680
  2. Ng FM, et al. "GH fragment fat metabolism." J Endocrinol, 2000. PMID: 10801956

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