Quick Facts

Chemical Name
Growth Hormone Releasing Factor (1-29)
Also Known As
GRF 1-29, Geref
Category
Growth Hormone
Administration
Subcutaneous injection, typically administered before bedtime to align with natural GH release patterns

What is Sermorelin?

Sermorelin is a truncated analog of natural growth hormone releasing hormone, containing amino acids 1-29 of the 44-amino acid native GHRH. This segment contains all the amino acids necessary for biological activity. Historically, it was FDA-approved for diagnostic use and pediatric growth hormone deficiency treatment. Sermorelin works by stimulating the pituitary gland to produce growth hormone naturally, offering a more physiological approach compared to direct GH replacement.

How Does Sermorelin Work?

Sermorelin binds to GHRH receptors on somatotroph cells in the anterior pituitary, triggering the release of stored growth hormone and stimulating new GH synthesis. This results in pulsatile GH release that mimics natural patterns. The hypothalamic-pituitary feedback mechanisms remain intact, reducing the risk of excessive GH levels. Additionally, sermorelin may help preserve the pituitary's ability to produce GH long-term.

Research-Backed Benefits

Natural GH Stimulation

Strong Evidence

Promotes physiological GH release patterns while maintaining feedback mechanisms.

FDA History

Strong Evidence

Has historical FDA approval, providing more safety and efficacy data than many peptides.

Anti-Aging Support

Moderate Evidence

May help address age-related decline in growth hormone levels.

Improved Sleep

Moderate Evidence

Often reported to enhance sleep quality and recovery.

Body Composition

Moderate Evidence

May support lean mass and healthy body composition with consistent use.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
100-300 mcg per dose
Frequency
Once daily, typically before bed
Duration
3-6 months for optimal effects

Best administered on an empty stomach, at least 2 hours after eating.

Side Effects & Safety

  • Injection site reactions
  • Flushing
  • Headache (rare)
  • Dizziness (rare)

Frequently Asked Questions

No, Sermorelin stimulates your body to produce its own growth hormone, while HGH is the hormone itself. This makes Sermorelin's approach more physiological.
Most people notice improved sleep within 2-4 weeks. Significant body composition changes typically require 3-6 months of consistent use.
Yes, Sermorelin (Geref) was FDA-approved for diagnostic purposes and pediatric GH deficiency treatment, though it has been discontinued as a commercial product.
Before bedtime is generally recommended to coincide with natural GH release patterns during sleep.

References

  1. Walker RF. "Sermorelin: A Review of Its Use in the Diagnosis and Treatment of GH Deficiency." Drugs, 2006. PMID: 16929329

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