Peptide Comparison

CJC-1295 vs Sermorelin

A detailed comparison to help you understand the differences and choose the right peptide for your research.

CJ

CJC-1295

Growth Hormone
VS
Se

Sermorelin

Growth Hormone

CJC-1295 and Sermorelin are both GHRH (Growth Hormone Releasing Hormone) analogs that stimulate natural GH production. While they share the same receptor target, key differences in structure and half-life affect how they're used. Understanding these differences helps optimize GH enhancement protocols.

Quick Comparison

Aspect
CJC-1295
Sermorelin
Structure
Modified 29-30 amino acids with stabilizing changes
First 29 amino acids of natural GHRH
Half-Life (no DAC)
~30 minutes
~10-20 minutes
Half-Life (with DAC)
6-8 days
N/A - no DAC version
Dosing Frequency
1-3x daily (no DAC) or 1-2x weekly (DAC)
1x daily (before bed)
FDA History
Research peptide only
Formerly FDA-approved for GH deficiency
GH Release Pattern
DAC: sustained; no DAC: pulsatile
Pulsatile, physiological
Research Volume
Extensive modern research
Decades of clinical data
Typical Use
Often with GHRP for synergy
Often used alone or with GHRP

Key Similarities

  • Both are GHRH analogs
  • Both stimulate pituitary GH release
  • Both maintain natural feedback mechanisms
  • Both can be combined with GHRPs
  • Both are generally well-tolerated
  • Both produce physiological GH patterns (no DAC versions)

Key Differences

  • CJC-1295 has a longer half-life
  • CJC-1295 DAC provides sustained GH elevation
  • Sermorelin has more clinical history
  • Sermorelin was FDA-approved (discontinued)
  • CJC-1295 no-DAC is more commonly paired with GHRPs
  • Sermorelin simpler dosing (once daily)

When to Choose Each

Choose CJC-1295

Choose CJC-1295 when you want flexibility between pulsatile (no DAC) and sustained (with DAC) GH release. The no-DAC version is excellent for combining with GHRPs for synergistic effects.

Choose Sermorelin

Choose Sermorelin for its extensive clinical history and straightforward once-daily dosing. It's well-suited for those who prefer a proven, traditional approach to GH enhancement.

Can You Stack Them?

Both peptides synergize with GHRPs like Ipamorelin. CJC-1295 no-DAC + Ipamorelin is one of the most popular combinations. Sermorelin + Ipamorelin is equally effective and commonly used in clinical settings.

Frequently Asked Questions

At equivalent protocols, they're similar. CJC-1295 DAC provides more sustained elevation, but no-DAC versions produce comparable pulsatile release.
No-DAC is preferred for more physiological pulsatile release and better synergy with GHRPs. DAC version provides convenience but sustained GH may not be ideal.
Yes, they work through the same mechanism and can be interchanged. Choose based on dosing preference and availability.

References

  1. Teichman SL, et al. "CJC-1295 GH effects." J Clin Endocrinol Metab, 2006. PMID: 16595485
  2. Walker RF. "Sermorelin review." Drugs, 2006. PMID: 16929329

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