Quick Facts

Chemical Name
Synthetic ACTH Analog
Also Known As
SEMAX, Heptapeptide ACTH (4-10)
Category
Cognitive & Neurological
Administration
Intranasal drops or spray are the most common delivery method

What is Semax?

Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH), specifically the fragment ACTH (4-10) with added Pro-Gly-Pro for stability. Developed in Russia, it has been approved there for treating stroke, cognitive disorders, and as a nootropic. Unlike ACTH, Semax has no hormonal effects but retains and enhances the neurotropic activities of the parent molecule.

How Does Semax Work?

Semax works through multiple mechanisms. It increases brain-derived neurotrophic factor (BDNF) and other neurotrophins, promoting neuroplasticity and neuronal survival. It modulates dopamine and serotonin systems, enhancing attention and mood. The peptide also has anti-inflammatory effects in the brain and may protect against oxidative stress. Its neuroprotective properties make it of interest for stroke recovery and neurodegenerative conditions.

Research-Backed Benefits

Cognitive Enhancement

Strong Evidence

Improves memory, attention, and learning through BDNF elevation.

Neuroprotection

Strong Evidence

Protects neurons from oxidative stress and ischemic damage.

Stroke Recovery

Moderate Evidence

Approved in Russia for stroke treatment and recovery.

Mood Improvement

Moderate Evidence

May alleviate symptoms of depression and anxiety.

ADHD Support

Emerging Research

Research suggests potential benefits for attention disorders.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
200-600 mcg per dose (0.1% solution)
Frequency
2-3 times daily
Duration
10-14 days, with breaks between cycles

Most commonly administered intranasally. Higher concentration (1%) available for specific conditions.

Side Effects & Safety

  • Generally well tolerated
  • Nasal irritation with intranasal use
  • Headache (uncommon)
  • Hair loss reported rarely with prolonged use

Frequently Asked Questions

Semax is used for cognitive enhancement, stroke recovery, and treating cognitive disorders. It's approved in Russia for these purposes.
No, while Semax is derived from ACTH, it has no hormonal effects. It only retains the neurotropic (brain-supporting) properties.
Intranasal Semax can produce noticeable effects within minutes to hours, with cumulative benefits over days of use.

References

  1. Ashmarin IP, et al. "Semax neuroprotective effects." Doklady Biological Sciences, 2005. PMID: 16358558

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