Quick Facts

Chemical Name
N-Hexanoic-Tyr-Ile-(6) aminohexanoic amide
Also Known As
PNB-0408
Category
Cognitive & Neurological
Administration
Oral or sublingual administration

What is Dihexa?

Dihexa is a modified peptide developed from angiotensin IV research. It's an orally active compound that dramatically enhances cognitive function through activation of the hepatocyte growth factor (HGF) system. Research suggests it may be millions of times more potent than BDNF at promoting synaptogenesis. Dihexa has been studied for cognitive enhancement and potential treatment of neurodegenerative conditions.

How Does Dihexa Work?

Dihexa acts as a potent agonist of the hepatocyte growth factor (HGF) receptor, also known as c-Met. Activation of this receptor promotes synaptogenesis—the formation of new synaptic connections between neurons. This is believed to underlie its cognitive-enhancing effects. Unlike many peptides, Dihexa is orally bioavailable and can cross the blood-brain barrier.

Research-Backed Benefits

Synaptogenesis

Moderate Evidence

Promotes formation of new synaptic connections, potentially enhancing learning and memory.

Memory Enhancement

Moderate Evidence

Animal studies show significant improvements in memory tasks.

Oral Bioavailability

Strong Evidence

Can be taken orally, unlike most peptides that require injection.

Neuroprotection

Emerging Research

May protect against cognitive decline through HGF system activation.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
10-20 mg orally or 5-10 mg sublingually
Frequency
Once daily
Duration
4-12 weeks

Orally active. Sublingual may provide better absorption. Very potent—start with low doses.

Side Effects & Safety

  • Limited human safety data
  • Potential for unknown long-term effects
  • May affect blood pressure
  • Headache reported rarely

Frequently Asked Questions

Dihexa has limited human safety data. While animal studies are promising, long-term effects in humans are unknown. Use with caution and ideally under medical supervision.
Research suggests Dihexa may be millions of times more potent than BDNF at promoting synaptogenesis, though this doesn't directly translate to experienced effects.
Animal research shows Dihexa can improve cognition in models of dementia. Human research for neurodegenerative conditions is still limited.

References

  1. McCoy AT, et al. "Dihexa cognitive enhancement." J Pharmacol Exp Ther, 2013. PMID: 23303266

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