Quick Facts

Chemical Name
Synthetic Tuftsin Analog
Also Known As
TP-7, Selanc
Category
Cognitive & Neurological
Administration
Intranasal spray for rapid onset or subcutaneous injection

What is Selank?

Selank is a heptapeptide derived from tuftsin, a naturally occurring tetrapeptide with immunomodulatory properties. Developed in Russia at the Institute of Molecular Genetics, it has been approved there for treating generalized anxiety disorder and as a nootropic. Selank combines the sequence of tuftsin with additional amino acids for stability, resulting in a peptide with both anxiolytic and cognitive-enhancing properties.

How Does Selank Work?

Selank modulates the expression of brain-derived neurotrophic factor (BDNF) and affects the balance of neurotransmitters including serotonin, dopamine, and norepinephrine. It also influences the GABAergic system without causing sedation or dependence. Additionally, Selank has immunomodulatory effects inherited from its tuftsin backbone. Its cognitive effects may be related to enhanced neuroplasticity and memory consolidation.

Research-Backed Benefits

Anxiety Reduction

Strong Evidence

Approved in Russia for generalized anxiety disorder with minimal sedation.

Cognitive Enhancement

Moderate Evidence

May improve memory, learning, and overall cognitive function.

Mood Stabilization

Moderate Evidence

Balances neurotransmitters and may improve mood without euphoria.

No Dependence

Moderate Evidence

Does not cause tolerance or withdrawal effects like benzodiazepines.

Immune Modulation

Emerging Research

May have beneficial effects on immune function.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
250-500 mcg per dose
Frequency
1-3 times daily
Duration
2-4 weeks, or as needed

Often administered intranasally for rapid onset. Subcutaneous injection is also used.

Side Effects & Safety

  • Generally very well tolerated
  • Mild fatigue (rare)
  • Nasal irritation with intranasal use
  • Headache (uncommon)

Frequently Asked Questions

Selank modulates GABA, serotonin, and other neurotransmitters without causing sedation. It increases BDNF and supports neuroplasticity.
No, unlike benzodiazepines, Selank does not cause tolerance, dependence, or withdrawal symptoms.
Selank is approved in Russia for generalized anxiety disorder and cognitive enhancement. It is not FDA-approved in the United States.

References

  1. Zozulya AA, et al. "Selank effects on anxiety." Bulletin of Experimental Biology and Medicine, 2001. PMID: 11687870

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