Quick Facts

Chemical Name
Brain-Derived Peptide Preparation
Also Known As
FPE 1070
Category
Cognitive & Neurological
Administration
Intravenous infusion or intramuscular injection

What is Cerebrolysin?

Cerebrolysin is a peptide preparation containing brain-derived neurotrophic factors derived from pig brain. It's been used clinically for over 50 years in many countries (though not FDA-approved in the US) for conditions including stroke, traumatic brain injury, and various dementias. The preparation mimics the action of endogenous neurotrophic factors, supporting neuronal survival, synaptic plasticity, and neurogenesis.

How Does Cerebrolysin Work?

Cerebrolysin contains active fragments of neurotrophic factors including NGF, BDNF, GDNF, and CNTF. These small peptides can cross the blood-brain barrier and activate neurotrophin signaling pathways. Effects include enhanced neuronal survival, increased synaptogenesis, improved synaptic plasticity, and potentially neurogenesis. It also has antioxidant and anti-inflammatory properties in the brain.

Research-Backed Benefits

Neurotrophic Support

Strong Evidence

Provides brain-derived growth factors that decline with age and injury.

Stroke Recovery

Strong Evidence

Clinical trials show benefits in stroke rehabilitation.

Cognitive Enhancement

Moderate Evidence

May improve memory and cognitive function in various conditions.

Neuroprotection

Moderate Evidence

Protects neurons against various toxic insults.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
10-30 mL IV or IM daily
Frequency
Daily during treatment cycles
Duration
10-20 days per cycle

Given by IV infusion or IM injection. Cycles often repeated. Medical supervision required.

Side Effects & Safety

  • Dizziness
  • Headache
  • Injection site reactions
  • Agitation (rare)
  • Allergic reactions possible (porcine derived)

Frequently Asked Questions

No, Cerebrolysin is not FDA-approved in the US but is approved in over 40 other countries for stroke, TBI, and dementia. It has over 50 years of clinical use internationally.
Cerebrolysin is given by IV infusion or intramuscular injection, typically in 10-20 day cycles. Oral administration is not effective due to peptide degradation.
While primarily used for neurological conditions, some use Cerebrolysin for cognitive enhancement. However, it requires injection and medical supervision.

References

  1. Ziganshina LE, et al. "Cerebrolysin stroke trials." Cochrane Database Syst Rev, 2020. PMID: 32766695

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