Quick Facts

Chemical Name
Mitochondrial-Derived Peptide Humanin
Also Known As
HN, HNG
Category
Longevity & Neuroprotection
Administration
Research peptide

What is Humanin?

Humanin is a 24-amino acid peptide encoded in the mitochondrial genome, making it one of the first recognized mitochondrial-derived peptides (MDPs). Discovered during research on Alzheimer's disease, it has demonstrated remarkable neuroprotective effects. Humanin levels decline with age, correlating with increased susceptibility to age-related diseases. Research suggests it may protect against various stressors and promote cellular survival.

How Does Humanin Work?

Humanin acts through multiple mechanisms including binding to IGFBP-3, activating STAT3 signaling, and interacting with BAX to prevent apoptosis. It protects cells from oxidative stress, amyloid-beta toxicity, and serum starvation. Humanin also improves insulin sensitivity and may influence systemic metabolism. Its cytoprotective effects appear to be broad-spectrum.

Research-Backed Benefits

Neuroprotection

Strong Evidence

Protects neurons against amyloid-beta toxicity and other insults.

Anti-Apoptotic

Strong Evidence

Prevents programmed cell death in various cell types.

Metabolic Benefits

Moderate Evidence

May improve insulin sensitivity and metabolic function.

Age-Related Decline

Moderate Evidence

Levels decrease with age, suggesting replacement benefit.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
Research protocols vary widely
Frequency
Daily or several times weekly
Duration
Weeks to months in research

Optimal human dosing not established. HNG (S14G variant) is more potent and stable.

Side Effects & Safety

  • Limited human safety data
  • Theoretical cancer concern (anti-apoptotic)
  • Unknown long-term effects
  • Research still early

Frequently Asked Questions

Humanin is encoded in mitochondrial DNA, not nuclear DNA, making it one of the first recognized mitochondrial-derived peptides. It has broad cytoprotective effects.
Cell and animal studies show Humanin protects against amyloid-beta toxicity. Human clinical trials are needed to confirm benefits in Alzheimer's disease.
Yes, HNG (S14G-Humanin) is a synthetic analog with greatly enhanced potency and stability. It's commonly used in research instead of native Humanin.

References

  1. Hashimoto Y, et al. "Humanin neuroprotection." Proc Natl Acad Sci, 2001. PMID: 11438707

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