Quick Facts

Chemical Name
Epitalon Tetrapeptide
Also Known As
Epitalon, Epithalone
Category
Longevity & Anti-Aging
Administration
Subcutaneous or intramuscular injection, used in cycles

What is Epithalon?

Epithalon (also spelled Epitalon) is a synthetic tetrapeptide consisting of alanine, glutamic acid, aspartic acid, and glycine (AGAG). It was developed by Russian scientist Vladimir Khavinson based on research into epithalamin, a peptide extract from the pineal gland. The primary interest in Epithalon centers on its potential to stimulate telomerase production, the enzyme that maintains telomere length and is associated with cellular longevity.

How Does Epithalon Work?

Epithalon is believed to work by stimulating telomerase production, which maintains and potentially lengthens telomeres - the protective caps at the ends of chromosomes. Telomere shortening is associated with cellular aging and senescence. By activating telomerase, Epithalon may help cells maintain their ability to divide and function properly. It may also influence melatonin production and circadian rhythm regulation.

Research-Backed Benefits

Telomerase Activation

Moderate Evidence

Research suggests it may stimulate telomerase activity, potentially affecting cellular aging.

Pineal Gland Function

Moderate Evidence

May support pineal gland function and melatonin production.

Sleep Regulation

Emerging Research

May improve sleep quality through effects on melatonin.

Cellular Longevity

Emerging Research

Potential to extend cellular replicative lifespan.

Antioxidant Properties

Emerging Research

May provide some antioxidant protection.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
5-10 mg per day
Frequency
Daily for 10-20 days
Duration
10-20 day cycles, often repeated 2-3 times per year

Typically used in cycles rather than continuously. Research protocols vary.

Side Effects & Safety

  • Generally well tolerated in research
  • Limited long-term human safety data
  • Potential injection site reactions
  • Effects on cancer risk are uncertain

Frequently Asked Questions

Epithalon is researched for its potential to activate telomerase, the enzyme that maintains telomere length. Telomere maintenance is associated with cellular longevity.
Epithalon has been used in research settings with few reported side effects, but long-term human safety data is limited. Concerns exist about potential effects on cancer risk.
Epithalon is typically used in cycles of 10-20 days, repeated several times per year, rather than continuously.

References

  1. Khavinson VK. "Peptide bioregulation of aging." Bulletin of Experimental Biology and Medicine, 2002. PMID: 12577695

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