Quick Facts

Chemical Name
Palmitoyl Pentapeptide-4
Also Known As
Pal-KTTKS, Matrixyl 3000
Category
Skin & Cosmetic
Administration
Topical application to face and neck

What is Matrixyl?

Matrixyl (Palmitoyl Pentapeptide-4) is a signal peptide that mimics fragments of collagen breakdown products, signaling the skin to produce more collagen. Originally developed by Sederma, it's become one of the most researched and widely used anti-aging peptides in skincare. Studies demonstrate significant improvements in wrinkle depth, skin roughness, and overall skin structure with regular use.

How Does Matrixyl Work?

When collagen breaks down, it releases small peptide fragments called matrikines, which signal fibroblasts to produce new collagen. Matrixyl mimics these matrikine signals, activating TGF-β pathways that upregulate collagen I, III, and IV production, as well as fibronectin and elastin synthesis. The palmitic acid modification enhances skin penetration.

Research-Backed Benefits

Collagen Stimulation

Strong Evidence

Signals skin to produce new collagen types I, III, and IV.

Wrinkle Reduction

Strong Evidence

Clinical studies show significant reduction in wrinkle depth and number.

Skin Texture Improvement

Strong Evidence

Improves skin roughness, density, and overall appearance.

Works Synergistically

Moderate Evidence

Combines well with other anti-aging ingredients for enhanced effects.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
Typically 3-8% in formulations
Frequency
1-2 times daily
Duration
8-12 weeks for visible results; ongoing for maintenance

Can be used AM and PM. Works well layered under other products.

Side Effects & Safety

  • Exceptionally well tolerated
  • Very rare irritation
  • Safe for sensitive skin
  • No sun sensitivity

Frequently Asked Questions

Matrixyl works through different mechanisms than retinol. While retinol increases cell turnover, Matrixyl directly signals collagen production. Many use both for complementary benefits.
Yes, Matrixyl is exceptionally well-tolerated and suitable for sensitive skin. It doesn't cause irritation like retinol can.
Matrixyl 3000 combines the original Matrixyl with palmitoyl tetrapeptide-7, which adds anti-inflammatory benefits. It's considered more advanced than the original formula.

References

  1. Robinson LR, et al. "Matrixyl wrinkle efficacy." Int J Cosmet Sci, 2005. PMID: 18492182

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