Quick Facts

Chemical Name
Acetyl Hexapeptide-3
Also Known As
Acetyl Hexapeptide-8, Argireline Peptide
Category
Skin & Cosmetic
Administration
Topical application to face, focusing on expression lines

What is Argireline?

Argireline (Acetyl Hexapeptide-3) is a synthetic peptide designed to reduce facial wrinkles through a mechanism similar to Botox but without injections. It works by inhibiting the SNARE complex, which is necessary for neurotransmitter release at the neuromuscular junction. By reducing muscle contractions, Argireline decreases expression lines and wrinkles. It's one of the most popular peptides in topical anti-aging skincare.

How Does Argireline Work?

Argireline inhibits the formation of the SNARE complex, which is required for acetylcholine release at neuromuscular junctions. Specifically, it mimics the N-terminus of SNAP-25, competing with the native protein. This reduces the signal that causes muscle contraction, leading to relaxation of facial muscles and reduction in expression wrinkles.

Research-Backed Benefits

Wrinkle Reduction

Strong Evidence

Reduces depth of expression wrinkles, particularly around eyes and forehead.

Non-Invasive Alternative

Moderate Evidence

Provides Botox-like effects without injections or downtime.

Preventive Use

Moderate Evidence

May help prevent new wrinkle formation with consistent use.

Safe Profile

Strong Evidence

Excellent safety record in topical application.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
5-10% concentration in topical formulations
Frequency
1-2 times daily
Duration
Ongoing use for maintained effects

Apply to clean, dry skin. Best used on expression areas: forehead, around eyes, between brows.

Side Effects & Safety

  • Generally very well tolerated
  • Rare skin irritation
  • Effects are temporary (not permanent muscle relaxation)
  • Less potent than injectable Botox

Frequently Asked Questions

Argireline is less potent than injectable Botox but provides a non-invasive alternative. Studies show 30% wrinkle reduction with consistent use, compared to higher percentages for Botox.
Initial effects may be seen in 2-4 weeks. Optimal results typically require 30-60 days of consistent twice-daily application.
Yes, Argireline works well with other skincare ingredients. It's often combined with GHK-Cu, retinol, and hyaluronic acid in formulations.

References

  1. Blanes-Mira C, et al. "Argireline wrinkle reduction." Int J Cosmet Sci, 2002. PMID: 18498503

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