Quick Facts

Chemical Name
Metastin (45-54)
Also Known As
KP-10, Kisspeptin
Category
Hormonal
Administration
Subcutaneous or intravenous injection in research settings

What is Kisspeptin-10?

Kisspeptin is a neuropeptide encoded by the KISS1 gene that plays a master regulatory role in reproduction. It was discovered through cancer research (as 'metastin') but is now recognized as essential for puberty initiation and reproductive function. Kisspeptin-10 is the shortest active fragment, potently stimulating GnRH neurons which in turn triggers LH and FSH release. It's being researched for fertility and hormone optimization.

How Does Kisspeptin-10 Work?

Kisspeptin binds to the KISS1R receptor (GPR54) on GnRH neurons in the hypothalamus, stimulating them to release gonadotropin-releasing hormone (GnRH). This triggers the pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which then act on the gonads. This makes kisspeptin a 'master switch' for the reproductive axis.

Research-Backed Benefits

LH/FSH Stimulation

Strong Evidence

Potently increases luteinizing hormone and follicle-stimulating hormone release.

Testosterone Support

Moderate Evidence

In men, LH stimulation leads to increased testosterone production.

Fertility Enhancement

Moderate Evidence

Being researched as a potential fertility treatment for both sexes.

Natural Axis Stimulation

Moderate Evidence

Works upstream, allowing natural hormone regulation to proceed.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
0.1-1 nmol/kg or fixed doses of 6.4-57 mcg
Frequency
Variable - from single doses to multiple daily
Duration
Research protocols vary widely

Dosing is complex and still being optimized in research. Various protocols exist.

Side Effects & Safety

  • Flushing
  • Headache possible
  • Limited long-term data
  • May affect reproductive hormones significantly

Frequently Asked Questions

Yes, by stimulating LH release, kisspeptin indirectly increases testosterone production in men. This makes it of interest for hormone optimization.
Kisspeptin is in clinical research for fertility applications, including IVF protocols. It shows promise as an alternative to HCG for triggering ovulation.
Both ultimately affect the reproductive axis, but kisspeptin works at the hypothalamic level (upstream) while HCG acts directly on gonads. Kisspeptin may allow more physiological hormone release.

References

  1. Dhillo WS, et al. "Kisspeptin reproductive effects." J Clin Endocrinol Metab, 2005. PMID: 16234304

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