Quick Facts

Chemical Name
Gonadotropin-Releasing Hormone
Also Known As
GnRH, LHRH
Category
Hormonal
Administration
Subcutaneous injection in pulsatile pattern

What is Gonadorelin?

Gonadorelin is a synthetic version of the naturally occurring gonadotropin-releasing hormone (GnRH). This decapeptide is released from the hypothalamus in pulses, triggering the pituitary to release LH and FSH. In clinical practice, it's used for fertility treatment, diagnostic testing, and increasingly to maintain testicular function during testosterone replacement therapy.

How Does Gonadorelin Work?

Gonadorelin binds to GnRH receptors on the anterior pituitary, stimulating release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Pulsatile administration mimics natural release patterns and maintains normal reproductive axis function. Continuous administration, paradoxically, downregulates the system (used in prostate cancer treatment).

Research-Backed Benefits

LH/FSH Release

Strong Evidence

Stimulates natural release of reproductive hormones from the pituitary.

Fertility Support

Strong Evidence

Used in fertility treatment for both men and women.

TRT Maintenance

Moderate Evidence

Can maintain testicular function and fertility during testosterone therapy.

Natural Hormone Pattern

Moderate Evidence

Pulsatile dosing maintains physiological hormone release patterns.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
100-500 mcg per dose
Frequency
2-3 times daily for TRT support; varies for fertility
Duration
Ongoing during TRT; cycles for other uses

Pulsatile administration is key. Continuous use causes opposite effect (suppression).

Side Effects & Safety

  • Injection site reactions
  • Headache
  • Flushing
  • Nausea (rare)

Frequently Asked Questions

Testosterone therapy suppresses natural hormone production, causing testicular atrophy. Gonadorelin maintains pituitary signaling, preserving testicular function and fertility.
Gonadorelin works at the pituitary level, stimulating natural LH release. HCG mimics LH directly at the gonads. Gonadorelin maintains more of the natural hormone cascade.
Gonadorelin can help stimulate the HPG axis, but results vary. It's often part of PCT (post-cycle therapy) protocols or used during TRT to maintain natural function.

References

  1. Conn PM, Crowley WF. "GnRH in clinical practice." N Engl J Med, 1991. PMID: 1944450

Get the Complete Gonadorelin Research Protocol

Join 50,000+ researchers with instant access to our comprehensive peptide resource.

Continue Your Research

Related Peptides