Quick Facts

Chemical Name
Delta Sleep-Inducing Peptide
Also Known As
Delta Sleep Peptide, DSIP
Category
Sleep & Recovery
Administration
Subcutaneous or intramuscular injection before bedtime

What is DSIP?

Delta Sleep-Inducing Peptide (DSIP) is a neuropeptide first isolated from rabbit brains in 1977. As its name suggests, it promotes delta wave sleep—the deepest and most restorative stage of sleep. Beyond sleep, DSIP has demonstrated stress-protective effects, can modulate cortisol and ACTH, and has analgesic properties. It's been studied for insomnia, stress, chronic pain, and even as an adjunct in addiction treatment.

How Does DSIP Work?

DSIP's mechanism is complex and not fully understood. It appears to modulate multiple neurotransmitter systems including GABAergic, glutamatergic, and opioid systems. It influences the hypothalamic-pituitary-adrenal (HPA) axis, reducing stress hormones. DSIP promotes delta wave sleep by affecting sleep-regulating neurons in the hypothalamus and brainstem.

Research-Backed Benefits

Deep Sleep Promotion

Moderate Evidence

Increases delta wave sleep, the most restorative sleep stage.

Stress Reduction

Moderate Evidence

Modulates HPA axis and may reduce cortisol levels.

Analgesic Effects

Moderate Evidence

Has demonstrated pain-reducing properties in research.

Hormone Regulation

Emerging Research

May help normalize disrupted LH, GH, and other hormone patterns.

Addiction Support

Emerging Research

Studied as adjunct therapy in alcohol and opioid withdrawal.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
100-300 mcg before bed
Frequency
Once daily at bedtime
Duration
2-4 weeks, or as needed

Best taken 30-60 minutes before intended sleep. Can be used cyclically or as needed.

Side Effects & Safety

  • Generally well tolerated
  • Possible grogginess if dose too high
  • Headache (rare)
  • Vivid dreams

Frequently Asked Questions

DSIP promotes natural delta wave sleep rather than sedation. It works with the body's sleep systems rather than forcing unconsciousness like many sleep medications.
DSIP may help with certain types of insomnia, particularly those involving disrupted sleep architecture. It's been studied for sleep disorders with positive results.
DSIP has not shown addiction potential in research. Unlike some sleep aids, it works with natural sleep mechanisms rather than creating dependence.

References

  1. Graf MV, Kastin AJ. "DSIP sleep effects." Pharmacol Rev, 1984. PMID: 6387707

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