Quick Facts

Chemical Name
Melanocortin Agonist Peptide
Also Known As
MT-II, MT2
Category
Metabolic & Other
Administration
Subcutaneous injection, typically started at low doses and titrated up

What is Melanotan 2?

Melanotan 2 is a synthetic cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (α-MSH). Originally developed at the University of Arizona for preventing skin cancer through tanning, it was never completed clinical trials for this purpose. MT-2 affects multiple melanocortin receptors, leading to various effects beyond just tanning, including appetite suppression and increased libido.

How Does Melanotan 2 Work?

Melanotan 2 is a non-selective agonist of melanocortin receptors MC1R through MC5R. Activation of MC1R stimulates melanin production in melanocytes, causing skin darkening. MC3R and MC4R activation affects appetite, metabolism, and sexual function. The peptide's broad receptor activity explains its diverse effects but also contributes to its side effect profile.

Research-Backed Benefits

Skin Tanning

Strong Evidence

Stimulates melanin production resulting in a tan without UV exposure.

Appetite Reduction

Moderate Evidence

MC4R activation may decrease appetite and food intake.

Libido Enhancement

Moderate Evidence

Often reported to increase sexual desire and function.

Fat Loss Support

Emerging Research

Melanocortin system activation may support metabolic rate.

Dosage Guidelines

Disclaimer: This content is for educational purposes only. Peptides are research compounds not approved by the FDA for human use. Always consult with a qualified healthcare provider.

Typical Range
250-500 mcg
Frequency
Daily during loading, then maintenance
Duration
2-4 weeks loading, followed by weekly maintenance

Typically started with low doses to assess tolerance. UV exposure enhances tanning effect.

Side Effects & Safety

  • Nausea (especially initially)
  • Facial flushing
  • Fatigue
  • Darkening of moles
  • Spontaneous erections (in males)

Frequently Asked Questions

Melanotan 2 is not FDA approved and has not completed clinical trials. Long-term safety data is limited, and there are concerns about effects on moles and melanoma risk.
Initial skin darkening is often noticed within 1-2 weeks. Full tanning effects typically develop over 4-6 weeks with consistent use.
While it can produce some darkening without sun, UV exposure significantly enhances and accelerates the tanning effect.
Melanotan 1 (afamelanotide) is more selective for MC1R and is FDA-approved for a rare condition. MT-2 activates multiple receptors and has broader effects.

References

  1. Hadley ME, Dorr RT. "Melanocortin peptides and their receptors." Peptides, 2006. PMID: 16289472

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